Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator
نویسندگان
چکیده
منابع مشابه
Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator
Matrix attachment regions (MAR) generally act as epigenetic regulatory sequences that increase gene expression, and they were proposed to partition chromosomes into loop-forming domains. However, their molecular mode of action remains poorly understood. Here, we assessed the possible contribution of the AT-rich core and adjacent transcription factor binding motifs to the transcription augmentin...
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The proteinaceous nuclear matrix of mammalian cell nuclei has been suggested to be involved in the regulation of eliminatili structure, DNA replication, and gene expression. Interaction between cellular DNA and the nuclear matrix is mediated by putative DNA binding sequences, matrix attachment regions (MARs), which may become altered during early events in cellular transformation. Among the cel...
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19 Veiga-da-Cunha, M., Courtois, S., Michel, A., Gosselain, E. and Van Schaftingen, E. (1996) J. Biol. Chem. 271,6292-6297 20 Charles, R. St., Harrison, R. W., Bell, G. I., Pilkis, S. J. and Weber, I. T. (1994) Diabetes 43, 784-791 21 Bennett, W. S. and Steitz, T. A. (1978) Proc. Natl. Acad. Sci. U.S.A. 75,4848-4852 22 Gidh-Jain, M., Takeda, J., Xu, L. Z., Lange, A. J., Vionnet, N., Stoffel, M....
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Regulatory elements for the mouse growth hormone (GH) gene are located distally in a putative locus control region (LCR) in addition to key elements in the promoter proximal region. The role of promoter DNA methylation for GH gene regulation is not well understood. Pit-1 is a POU transcription factor required for normal pituitary development and obligatory for GH gene expression. In mammals, Pi...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0079262